Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells.

@article{Grzywacz2006CoordinatedAO,
  title={Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells.},
  author={Bartosz J Grzywacz and Nandini Kataria and Magdalena Sikora and Robert A. J. Oostendorp and Elaine Dzierzak and Bruce R Blazar and Jeffrey S Miller and Michael R. Verneris},
  journal={Blood},
  year={2006},
  volume={108 12},
  pages={3824-33}
}
The stages of human natural killer (NK) cell differentiation are not well established. Culturing CD34(+) progenitors with interleukin 7 (IL-7), IL-15, stem cell factor (SCF), FLT-3L, and murine fetal liver cell line (EL08.1D2), we identified 2 nonoverlapping subsets of differentiating CD56(+) cells based on CD117 and CD94 (CD117(high)CD94(-) and CD117(low/-)CD94(+) cells). Both populations expressed CD161 and NKp44, but differed with respect to NKp30, NKp46, NKG2A, NKG2C, NKG2D, CD8, CD16, and… CONTINUE READING