Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

@article{Panda2002CoordinatedTO,
  title={Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock},
  author={Satchidananda Panda and Marina P. Antoch and Brooke H. Miller and Andrew I. Su and Andrew B. Schook and Martin Straume and Peter G. Schultz and Steve A. Kay and Joseph S. Takahashi and John B. Hogenesch},
  journal={Cell},
  year={2002},
  volume={109},
  pages={307-320}
}
In mammals, circadian control of physiology and behavior is driven by a master pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene expression profiling to identify cycling transcripts in the SCN and in the liver. Our analysis revealed approximately 650 cycling transcripts and showed that the majority of these were specific to either the SCN or the liver. Genetic and genomic analysis suggests that a relatively small number of output genes are directly… Expand

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