Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a*

  title={Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a*},
  author={Xiaoli Wu and Mihir K Bhayani and Cristina T. Dodge and Milena Sabrina Nicoloso and Yunyun Chen and Xiaofeng Yan and Makoto Adachi and Ligy Thomas and Chad E. Galer and Tilahun W Jiffar and Curtis R. Pickering and Michael E. Kupferman and Jeffrey N. Myers and George A. Calin and Stephen Y Lai},
Epidermal growth factor receptor (EGFR) has been characterized as a critical factor in the development and progression of multiple solid tumors, including head and neck squamous cell carcinoma (HNSCC). However, monotherapy with EGFR-specific agents has not been as dramatic as preclinical studies have suggested. Since complex regulation of the EGFR signaling… CONTINUE READING