Coordinated Reset Deep Brain Stimulation of Subthalamic Nucleus Produces Long-Lasting, Dose-Dependent Motor Improvements in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Non-Human Primate Model of Parkinsonism.

@article{Wang2016CoordinatedRD,
  title={Coordinated Reset Deep Brain Stimulation of Subthalamic Nucleus Produces Long-Lasting, Dose-Dependent Motor Improvements in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Non-Human Primate Model of Parkinsonism.},
  author={Jing Wang and Shane D Nebeck and Abirami Muralidharan and Matthew D. Johnson and Jerrold L. Vitek and Kenneth B. Baker},
  journal={Brain stimulation},
  year={2016},
  volume={9 4},
  pages={609-17}
}
BACKGROUND Novel deep brain stimulation (DBS) paradigms are being explored in an effort to further optimize therapeutic outcome for patients with Parkinson's disease (PD). One approach, termed 'Coordinated Reset' (CR) DBS, was developed to target pathological oscillatory network activity. with desynchronizing effects and associated therapeutic benefit hypothesized to endure beyond cessation of stimulus delivery. OBJECTIVE To characterize the acute and carry-over effects of low-intensity CR… CONTINUE READING
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