Coordinated Regulation of Synaptic Plasticity at Striatopallidal and Striatonigral Neurons Orchestrates Motor Control.

@article{Trusel2015CoordinatedRO,
  title={Coordinated Regulation of Synaptic Plasticity at Striatopallidal and Striatonigral Neurons Orchestrates Motor Control.},
  author={Massimo Trusel and Anna Cavaccini and Marta Gritti and Barbara Greco and P. Saintot and Cristiano Nazzaro and Milica Cerovic and Ilaria Maria Morella and Riccardo Brambilla and Raffaella Tonini},
  journal={Cell reports},
  year={2015},
  volume={13 7},
  pages={1353-1365}
}
The basal ganglia play a critical role in shaping motor behavior. For this function, the activity of medium spiny neurons (MSNs) of the striatonigral and striatopallidal pathways must be integrated. It remains unclear whether the activity of the two pathways is primarily coordinated by synaptic plasticity mechanisms. Using a model of Parkinson's disease, we determined the circuit and behavioral effects of concurrently regulating cell-type-specific forms of corticostriatal long-term synaptic… CONTINUE READING