Coordinated Regulation of Lymph Node Vascular–Stromal Growth First by CD11c+ Cells and Then by T and B Cells

@article{Chyou2011CoordinatedRO,
  title={Coordinated Regulation of Lymph Node Vascular–Stromal Growth First by CD11c+ Cells and Then by T and B Cells},
  author={S. Chyou and F. Benahmed and Jingfeng Chen and Varsha Kumar and S. Tian and M. Lipp and T. Lu},
  journal={The Journal of Immunology},
  year={2011},
  volume={187},
  pages={5558 - 5567}
}
Lymph node blood vessels play important roles in the support and trafficking of immune cells. The blood vasculature is a component of the vascular–stromal compartment that also includes the lymphatic vasculature and fibroblastic reticular cells (FRCs). During immune responses as lymph nodes swell, the blood vasculature undergoes a rapid proliferative growth that is initially dependent on CD11c+ cells and vascular endothelial growth factor (VEGF) but is independent of lymphocytes. The lymphatic… Expand
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