Coordinated Redistribution of Leukocyte LFA-1 and Endothelial Cell ICAM-1 Accompany Neutrophil Transmigration

@article{Shaw2004CoordinatedRO,
  title={Coordinated Redistribution of Leukocyte LFA-1 and Endothelial Cell ICAM-1 Accompany Neutrophil Transmigration},
  author={Sunil K. Shaw and Shuo Nan Ma and Michael B. Kim and Ravi M. Rao and Charles U. Hartman and Richard M. Froio and Lin Yang and Todd D. Jones and Yuan Liu and Asma Nusrat and Charles A Parkos and Francis W. Luscinskas},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={200},
  pages={1571 - 1580}
}
The leukocyte integrin lymphocyte function-associated antigen 1 (LFA-1) and its endothelial ligand intercellular adhesion molecule (ICAM)-1 play an important role in transmigration as demonstrated by in vivo and in vitro models of inflammation. Despite the prominent role, little is known concerning the distribution and dynamic behavior of these adhesion molecules during leukocyte transmigration. Therefore, we examined the spatial and temporal distribution of LFA-1 on neutrophils actively… CONTINUE READING
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Adhesion structure subpanel 1, E rosetting/GPI anchor: CD2, CD48, CD55, CD58, CD59, CD99, and CDw108

  • L. B. Klickstein, T. A. Springer
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