Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1/CREB2.

@article{Butscher1998CoordinateTO,
  title={Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1/CREB2.},
  author={Wayne G Butscher and Ciaran Powers and Michael Olive and Charles Vinson and Kevin Gardner},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 1},
  pages={552-60}
}
The interleukin-2 CD28 response element (CD28RE) acts as a composite enhancer, in conjunction with a 3'-12-O-tetradecanoylphorbol-13-acetate response element (TRE)-like element, to confer CD28 receptor-dependent inducibility to the interleukin-2 promoter in T-cells. When inserted as a single copy upstream of a basal promoter, this composite enhancer, termed… CONTINUE READING