Coordinate regulation of the gel-forming mucin genes at chromosome 11p15.5.

  title={Coordinate regulation of the gel-forming mucin genes at chromosome 11p15.5.},
  author={Nehal Gosalia and Shih-Hsing Leir and Ann Marie Harris},
  journal={The Journal of biological chemistry},
  volume={288 9},
Four of the genes that encode gel-forming mucins, which are major components of the mucus layer protecting many epithelial surfaces, are clustered at chromosome 11p15.5 and show both cell- and tissue-specific expression patterns. We aimed to determine whether the individual genes were coordinately regulated by mechanisms involving higher order chromatin structure. CCCTC-binding factor (CTCF) sites were predicted in silico and CTCF occupancy then evaluated by chromatin immunoprecipitation. CTCF… CONTINUE READING
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