Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

Abstract

We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an in vitro transfer, AML exosomes produce proangiogenic changes in bystander cells. We reasoned that paracrine exosome trafficking may have a broader role in shaping the leukemic niche. In a series of in… (More)
DOI: 10.1038/leu.2015.163

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