Coordinate regulation of renal expression of nitric oxide synthase, renin, and angiotensinogen mRNA by dietary salt.

@article{Singh1996CoordinateRO,
  title={Coordinate regulation of renal expression of nitric oxide synthase, renin, and angiotensinogen mRNA by dietary salt.},
  author={Inderjit Singh and Morgan E Grams and Wenhui Wang and Tianxin Yang and Paul D. Killen and Ann M Smart and J{\"u}rgen B. Schnermann and Josephine P. Briggs},
  journal={The American journal of physiology},
  year={1996},
  volume={270 6 Pt 2},
  pages={F1027-37}
}
Experiments were performed to examine the effect of changes in dietary salt intake on the neuronal form of the constitutive nitric oxide synthase (ncNOS, type I NOS), renin, and angiotensinogen mRNA expression in the kidney. Three groups of Sprague-Dawley rats were studied as follows: rats maintained on a 3% Na diet plus 0.45% NaCl in the drinking fluid for 7 days (high salt), rats given a single injection of furosemide (2 mg/kg i.p.) and a 0.03% Na diet for 7 days (low salt), and rats on a… CONTINUE READING

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