Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.

@article{Sriburi2007CoordinateRO,
  title={Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.},
  author={Rungtawan Sriburi and Hemamalini Bommiasamy and Gerald L Buldak and G. Robbins and Matthew Frank and Suzanne Jackowski and Joseph W. Brewer},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 10},
  pages={7024-34}
}
Development of the expansive endoplasmic reticulum (ER) present in specialized secretory cell types requires X-box-binding protein-1 (Xbp-1). Enforced expression of XBP-1(S), a transcriptional activator generated by unfolded protein response-mediated splicing of Xbp-1 mRNA, is sufficient to induce proliferation of rough ER. We previously showed that XBP-1(S)-induced ER biogenesis in fibroblasts correlates with increased production of phosphatidylcholine (PtdCho), the primary phospholipid of the… CONTINUE READING