Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease.

@article{Congiu2009CoordinateRO,
  title={Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease.},
  author={Mario Congiu and Maurice L. Mashford and John L. Slavin and Paul Vincent Desmond},
  journal={Journal of gastroenterology and hepatology},
  year={2009},
  volume={24 6},
  pages={
          1038-44
        }
}
BACKGROUND It has been hypothesised, mainly from studies with animal models of liver disease, that the transport of substrates for metabolic enzymes and their subsequent metabolism and elimination in hepatic bile or blood is co-ordinated, but there is little information on this process in diseased human liver. METHODS In this study we have measured by reverse transcription polymerase chain reaction (RT-PCR) major genes involved in drug metabolism from UDP-glucuronosyltransferases (UGT1A1… CONTINUE READING
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