Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart.

@article{Harrer1997CoordinateRO,
  title={Coordinate regulation of SR Ca(2+)-ATPase and phospholamban expression in developing murine heart.},
  author={Judy M. Harrer and Kobra Haghighi and Ha Won Kim and Donald G. Ferguson and Evangelia G Kranias},
  journal={The American journal of physiology},
  year={1997},
  volume={272 1 Pt 2},
  pages={H57-66}
}
Phospholamban, the regulator of Ca(2+)-adenosinetriphosphatase (ATPase) activity in cardiac sarcoplasmic reticulum (SR), is an important determinant of basal myocardial performance. To determine whether phospholamban expression is developmentally regulated in the mouse and whether such regulation reflects alterations in Ca2+ pump activity, hearts from different stages of development were processed for molecular biological and biochemical studies. Both phospholamban and Ca(2+)-ATPase mRNAs were… CONTINUE READING