Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.

  title={Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.},
  author={Vincent Dahirel and K. Shekhar and Florencia Pereyra and Toshiyuki Miura and Mikita Artyomov and Shiv Talsania and Todd M. Allen and Marcus Altfeld and Mary Carrington and Darrell J Irvine and Bruce D. Walker and Arup K. Chakraborty},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 28},
Cellular immune control of HIV is mediated, in part, by induction of single amino acid mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we sought to determine if higher order constraints on viral evolution exist, because some coordinately linked combinations of mutations may hurt viability. Immune targeting of multiple sites in such a multidimensionally conserved region might render the virus particularly vulnerable, because viable escape pathways would… CONTINUE READING

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