Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence

@article{Endoh2008CoordinateEO,
  title={Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence},
  author={Morio Endoh and Yusuke Kobayashi and Yoshimi Yamakami and Ryuzo Yonekura and Michihiko Fujii and Dai Ayusawa},
  journal={Biogerontology},
  year={2008},
  volume={10},
  pages={213-221}
}
Pregnancy-specific glycoproteins (PSGs) comprise a family of highly similar polypeptides encoded by 11 transcriptionally active genes that compactly cluster on band 19q13.2. All members of the PSG family were found to be markedly up-regulated by addition of 5-bromodeoxyuridine in HeLa cells. Similarly, all of the members were markedly up-regulated during replicative senescence in normal human fibroblasts. Promoter analysis of the PSG1, 4, and 11 genes in HeLa cells did not reveal a cis… CONTINUE READING
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