Coordinate expression of cytolytic activity and cytotoxic T cell-specific carbohydrate antigens in a T cell hybridoma.

@article{Lefranois1986CoordinateEO,
  title={Coordinate expression of cytolytic activity and cytotoxic T cell-specific carbohydrate antigens in a T cell hybridoma.},
  author={Leo Lefrançois and Osami Kanagawa},
  journal={Journal of immunology},
  year={1986},
  volume={136 4},
  pages={1171-7}
}
The expression of cytotoxic T lymphocyte (CTL)-specific carbohydrate antigens (termed CT antigens) was studied by using a cytolytically inducible T cell hybridoma, KSH4.13.6. Expression of the CT determinants occurred concomitantly with the expression of cytolytic activity after induction of the hybrid with supernatants from Con A-activated rat spleen cells. Purified IL 2 was also proven to be effective in inducing cytolytic activity and CT antigen expression, but the time course of activation… CONTINUE READING