Coordinate expression of CC chemokine ligand 5, granulysin, and perforin in CD8+ T cells provides a host defense mechanism against Mycobacterium tuberculosis.

@article{Stegelmann2005CoordinateEO,
  title={Coordinate expression of CC chemokine ligand 5, granulysin, and perforin in CD8+ T cells provides a host defense mechanism against Mycobacterium tuberculosis.},
  author={Frank Stegelmann and Max Bastian and Kay Swoboda and Rauf Bhat and Viviane Kiessler and Alan M. Krensky and Martin Roellinghoff and Robert L Modlin and Steffen Stenger},
  journal={Journal of immunology},
  year={2005},
  volume={175 11},
  pages={7474-83}
}
The ability of CD8+ T cells to kill intracellular pathogens depends upon their capacity to attract infected cells as well as their secretion of cytolytic and antimicrobial effector molecules. We examined the Ag-induced expression of three immune effector molecules contained within cytoplasmic granules of human CD8+ T cells: the chemokine CCL5, the cytolytic molecule perforin, and the antimicrobial protein granulysin. Macrophages infected with virulent Mycobacterium tuberculosis triggered the… CONTINUE READING

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