Coordinate decrease of tissue insulinlike growth factor I posttranscriptional alternative mRNA transcripts in diabetes mellitus.

Abstract

In these studies, we examined the effect of excess levels of growth hormone (GH) on rat insulinlike growth factor I (IGF-I) gene expression in streptozocin-induced diabetes mellitus. A solution hybridization/RNase protection assay was used to simultaneously quantitate the relative tissue content of the variant IGF-I mRNA species arising from alternative… (More)

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@article{Fagin1989CoordinateDO, title={Coordinate decrease of tissue insulinlike growth factor I posttranscriptional alternative mRNA transcripts in diabetes mellitus.}, author={James A. Fagin and Charles Roberts and Derek Leroith and A T Brown}, journal={Diabetes}, year={1989}, volume={38 4}, pages={428-34} }