Coordinate control of host DNA synthesis and measles virus production in persistently infected BHK-21 cells

  title={Coordinate control of host DNA synthesis and measles virus production in persistently infected BHK-21 cells},
  author={I. Prasad},
  journal={Archives of Virology},
  • I. Prasad
  • Published 2005
  • Biology, Medicine
  • Archives of Virology
SummaryMeasles virus, upon infection, caused cytopathic effects in BHK-21 cells while it readily established persistent infection in a mutant strain of BHK-21 cells which possessed a temperature sensitive defect in DNA synthesis (BN2). This finding demonstrated that host function can be involved in allowing the establishment of persistent infection. When BN2 and infected BN2 cells were incubated at the non-permissive temperature (39.5° C), DNA synthesis was inhibited in a similar manner in both… Expand
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