Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.

@article{Mosser1988CoordinateCI,
  title={Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.},
  author={Dick D. Mosser and Nicholas G. Theodorakis and Richard I. Morimoto},
  journal={Molecular and cellular biology},
  year={1988},
  volume={8 11},
  pages={4736-44}
}
Activation of human heat shock gene transcription by heat shock, heavy metal ions, and amino acid analogs required the heat shock element (HSE) in the HSP70 promoter. Both heat shock- and metal ion-induced HSP70 gene transcription occurred independently of protein synthesis, whereas induction by amino acid analogs required protein synthesis. We identified a HSE-binding activity from control cells which was easily distinguished by a gel mobility shift assay from the stress-induced HSE-binding… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 127 extracted citations

Inhibition of the heat shock response by PI103 enhances the cytotoxicity of arsenic trioxide.

Toxicological sciences : an official journal of the Society of Toxicology • 2012
View 3 Excerpts
Highly Influenced

Three heat shock proteins from Spodoptera exigua: Gene cloning, characterization and comparative stress response during heat and cold shocks.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology • 2011
View 4 Excerpts
Highly Influenced

Mammalian SWI-SNF complexes contribute to activation of the hsp70 gene.

Molecular and cellular biology • 2000
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Heat - inducible human factor that binds to a human hsp 7 O promoter

S. Lindquist
Mol . Cell . Biol . • 1987

Purification and characterization of a heat - shock element binding protein from yeast

G. W. Stuart, P. F. Searle, H. Y. Chen, R. L. Brinster, R. D. Palmiter
EMBO J . • 1987

Similar Papers

Loading similar papers…