Coordinate assembly of lipids and enzyme proteins into epidermal lamellar bodies.

@article{Rassner1999CoordinateAO,
  title={Coordinate assembly of lipids and enzyme proteins into epidermal lamellar bodies.},
  author={Ulrich Rassner and Kenneth R. Feingold and Debra A. Crumrine and Peter M Elias},
  journal={Tissue & cell},
  year={1999},
  volume={31 5},
  pages={489-98}
}
Formation of the epidermal permeability barrier requires delivery of lamellar body (LB) contents to the stratum corneum interstices. LB are enriched in a mixture of polar lipids and a family of hydrolytic enzymes, required for the extracellular processing of the secreted polar lipids into the more hydrophobic products which mediate barrier function. Prior non-quantitative studies show that acute barrier disruption leads to immediate secretion of the contents of performed LB from the outermost… CONTINUE READING

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