Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice

@article{Ma2011CoordinateAO,
  title={Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice},
  author={Wenbin Ma and Blanca Ort{\'i}z-Quintero and Roberto Rangel and Morgan R. McKeller and Sara Herrera-Rodriguez and Eliseo F Castillo and Kimberly S. Schluns and Mary Hall and Huiyuan Zhang and Woong-Kyung Suh and Hitoshi Okada and Tak W Mak and Yang Zhou and Michael R. Blackburn and Hector Martinez-Valdez},
  journal={Cell Research},
  year={2011},
  volume={21},
  pages={1564-1577}
}
Gene expression can be regulated by chromatin modifiers, transcription factors and proteins that modulate DNA architecture. Among the latter, AT-hook transcription factors have emerged as multifaceted regulators that can activate or repress broad A/T-rich gene networks. Thus, alterations of AT-hook genes could affect the transcription of multiple genes causing global cell dysfunction. Here we report that targeted deletions of mouse AKNA, a hypothetical AT-hook-like transcription factor… CONTINUE READING