Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities

@article{Filbin2013CoordinateAO,
  title={Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities},
  author={Mariella G Filbin and Sukriti K. Dabral and Maria F. Pazyra-Murphy and Shakti H. Ramkissoon and Andrew Kung and Ekaterina Pak and Jarom Yan-Ming Chung and Matthew A Theisen and Yanping Sun and Yoko Franchetti and Yu Sun and David S Shulman and Navid Redjal and B Mauriclo Tabak and Rameen Beroukhim and Qi Fa Wang and Jean Jianquin Cincinnati Zhao and Marion Dorsch and Silvia Buonamici and Keith L Ligon and Joseph F. Kelleher and Rosalind A. Segal},
  journal={Nature Medicine},
  year={2013},
  volume={19},
  pages={1518-1523}
}
In glioblastoma, phosphatidylinositol 3-kinase (PI3K) signaling is frequently activated by loss of the tumor suppressor phosphatase and tensin homolog (PTEN). However, it is not known whether inhibiting PI3K represents a selective and effective approach for treatment. We interrogated large databases and found that sonic hedgehog (SHH) signaling is activated in PTEN-deficient glioblastoma. We demonstrate that the SHH and PI3K pathways synergize to promote tumor growth and viability in human PTEN… CONTINUE READING
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