Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia.

@article{Lukiw2003CoordinateAO,
  title={Coordinate activation of HIF-1 and NF-kappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia.},
  author={Walter J. Lukiw and Anna Ottlecz and George N. Lambrou and Monika Grueninger and Joelle Finley and Hilary W. Thompson and Nicolas G Bazan},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 10},
  pages={4163-70}
}
PURPOSE Proinflammatory signaling mechanisms are implicated in the induction of retinal neovascularization (NV) during ischemic retinopathies. This study examined transcription factor (TF) AP-1, HIF-1, and NF-kappaB DNA-binding in relation to cyclooxygenase (COX)-2 and VEGF RNA and protein levels in hypoxia-triggered monkey choroidal retinal (RF/6A… CONTINUE READING