Coordinate Regulation of G Protein Signaling via Dynamic Interactions of Receptor and GAP

@article{Turcotte2008CoordinateRO,
  title={Coordinate Regulation of G Protein Signaling via Dynamic Interactions of Receptor and GAP},
  author={Marc Turcotte and Wei Tang and Elliott M. Ross},
  journal={PLoS Computational Biology},
  year={2008},
  volume={4},
  pages={795 - 827}
}
Signal output from receptor-G-protein-effector modules is a dynamic function of the nucleotide exchange activity of the receptor, the GTPase-accelerating activity of GTPase-activating proteins (GAPs), and their interactions. GAPs may inhibit steady-state signaling but may also accelerate deactivation upon removal of stimulus without significantly inhibiting output when the receptor is active. Further, some effectors (e.g., phospholipase C-beta) are themselves GAPs, and it is unclear how such… CONTINUE READING
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