Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK.

@article{Wang2002CoordinateNT,
  title={Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK.},
  author={Wenli Wang and Alexandre Holthausen Campos and Chengyu Z. Prince and Yongshan Mou and Matthew J. Pollman},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 26},
  pages={23165-71}
}
The Notch family of receptors and downstream effectors plays a critical role in cell fate determination during vascular ontogeny. Moreover, the human cerebral autosomal dominant artriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) syndrome of premature stroke and dementia is a heritable arteriopathy with alterations in vascular smooth muscle cells (VSMCs) resulting from mutations within Notch3. However, the expression and regulation of the Notch and hairy-related… CONTINUE READING
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