Coordinate Control of Proliferation and Migration by the p27/Cyclin-Dependent Kinase/Retinoblastoma Pathway in Vascular Smooth Muscle Cells and Fibroblasts


Previous studies have demonstrated a protective effect of the cyclin-dependent kinase (CDK) inhibitor p27 against atherosclerosis and restenosis, two disorders characterized by abundant proliferation and migration of vascular smooth muscle cells and adventitial fibroblasts. These therapeutic effects might result from p27-dependent suppression of both cell… (More)


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