Coordinate Activation of Activator Protein 1 and Inflammatory Cytokines in Response to Neisseria gonorrhoeae Epithelial Cell Contact Involves Stress Response Kinases

@article{Naumann1998CoordinateAO,
  title={Coordinate Activation of Activator Protein 1 and  Inflammatory Cytokines in Response to Neisseria gonorrhoeae  Epithelial Cell Contact Involves Stress Response Kinases },
  author={Michael Naumann and Thomas Rudel and Bj{\"o}rn Wieland and Christian Bartsch and Thomas F. Meyer},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={188},
  pages={1277 - 1286}
}
Neisseria gonorrhoeae (Ngo), the etiologic agent of gonorrhea, induce a number of proinflammatory cytokines by contact to epithelial cells. Cytokine genes and a variety of other immune response genes are activated as a result of the regulatory function of immediate early response transcription factors including activator protein 1 (AP-1). Since it is established that phosphorylation of c-Jun, the central component of AP-1, by the stress-activated c-Jun NH2-terminal kinase (JNK) increases the… CONTINUE READING

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