Cooperativity of hydrophobic anchor interactions: evidence for epitope selection by MHC class II as a folding process.

@article{Ferrante2007CooperativityOH,
  title={Cooperativity of hydrophobic anchor interactions: evidence for epitope selection by MHC class II as a folding process.},
  author={Andrea Ferrante and Jack Gorski},
  journal={Journal of immunology},
  year={2007},
  volume={178 11},
  pages={
          7181-9
        }
}
Peptide binding to MHC class II (MHCII) molecules is stabilized by hydrophobic anchoring and hydrogen bond formation. We view peptide binding as a process in which the peptide folds into the binding groove and to some extent the groove folds around the peptide. Our previous observation of cooperativity when analyzing binding properties of peptides modified at side chains with medium to high solvent accessibility is compatible with such a view. However, a large component of peptide binding is… CONTINUE READING

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The PyMOL Molecular Graphics System

  • W. L. De Lano
  • De Lano Scientific, San Carlos,
  • 2002
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