Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia.

@article{Johnson2015CooperativityOH,
  title={Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia.},
  author={Susan S Johnson and Michael A Eller and Jeffrey E. Teigler and Sebastien M Maloveste and Bruce T Schultz and Damien Z. Soghoian and Richard Lu and Alexander F Oster and A. -L. Chenine and Galit Alter and Ulf Dittmer and Mary A. Marovich and Merlin L. Robb and Nelson L Michael and Diane L Bolton and Hendrik Streeck},
  journal={Journal of virology},
  year={2015},
  volume={89 15},
  pages={
          7494-505
        }
}
UNLABELLED CD4+ T cells play a pivotal role in the control of chronic viral infections. Recently, nontraditional CD4+ T cell functions beyond helper effects have been described, and a role for cytolytic CD4+ T cells in the control of HIV infection has been suggested. We define here the transcriptional, phenotypic, and functional profiles of HIV-specific cytolytic CD4+ T cells. Fluidigm BioMark and multiparameter flow cytometric analysis of HIV-specific cytolytic CD4+ T cells revealed a distinct… CONTINUE READING
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