Cooperativity in the binding of 1 alpha,25-dihydroxyvitamin D3 to the chick intestinal receptor.

@article{Wilhelm1984CooperativityIT,
  title={Cooperativity in the binding of 1 alpha,25-dihydroxyvitamin D3 to the chick intestinal receptor.},
  author={Friedrich Wilhelm and Anthony W. Norman},
  journal={FEBS letters},
  year={1984},
  volume={170 2},
  pages={239-42}
}
The binding of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] to its chick intestinal receptor does not fit well to the linear regression line of Scatchard's model (r = -0.79; dissociation constant, Kd = 0.51 nM). In fact, a concave 'hook' curve describes the data better. By using the Hill analysis the linear fitting was improved (r = 0.99), the Kd was found to be… CONTINUE READING