Cooperativity between the hydrophobic and cross-linking domains of elastin.

@article{Kumashiro2006CooperativityBT,
  title={Cooperativity between the hydrophobic and cross-linking domains of elastin.},
  author={Kristin K. Kumashiro and Joanna P Ho and Walter P. Niemczura and Fred W. Keeley},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 33},
  pages={23757-65}
}
The principal protein component of the elastic fiber found in elastic tissues is elastin, an amorphous, cross-linked biopolymer that is assembled from a high molecular weight monomer. The hydrophobic and cross-linking domains of elastin have been considered separate and independent, such that changes to one region are not thought to affect the other. However, results from these solid-state 13C NMR experiments demonstrate that cooperativity in protein folding exists between the two domain types… CONTINUE READING