Cooperativity between mutations in tyrosine kinases and in hematopoietic transcription factors in AML

@article{Deguchi2002CooperativityBM,
  title={Cooperativity between mutations in tyrosine kinases and in hematopoietic transcription factors in AML},
  author={Katsuya Deguchi and D G Gilliland},
  journal={Leukemia},
  year={2002},
  volume={16},
  pages={740-744}
}
Chronic myeloid leukemia (CML) syndromes are characterized by a proliferative and/or survival advantage of myeloid lineage cells, with normal myeloid maturation and differentiation. At least six distinct chromosomal translocations have been associated with this phenotype in humans, of which the most common is the t(9;22) giving rise to BCR/ABL fusion protein. Each of these translocations associated with CML syndromes have been cloned, and invariably result in the expression of a fusion protein… CONTINUE READING

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Efficacy of STI 571 , an Abl tyrosine kinase inhibitor , in conjunction with other antileukemic agents against BcrAblpositive cells

  • J Theising, S Ohno-Jones, K Kolibaba, B Druker
  • Blood
  • 2000

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