Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum.

@article{Liebau2005CooperativityAP,
  title={Cooperativity and pseudo-cooperativity in the glutathione S-transferase from Plasmodium falciparum.},
  author={Eva Liebau and Francesca De Maria and C. D. Burmeister and Markus Perbandt and Paola Turella and Giovanni Antonini and Giorgio Federici and Francesco Giansanti and Lorenzo Stella and Mario Lo Bello and Anna Maria Caccuri and Giorgio Ricci},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 28},
  pages={26121-8}
}
Binding and catalytic properties of glutathione S-transferase from Plasmodium falciparum (PfGST) have been studied by means of fluorescence, steady state and pre-steady state kinetic experiments, and docking simulations. This enzyme displays a peculiar reversible low-high affinity transition, never observed in other GSTs, which involves the G-site and… CONTINUE READING