Cooperativity: over the Hill.

  title={Cooperativity: over the Hill.},
  author={Sture Fors{\'e}n and Sara Linse},
  journal={Trends in biochemical sciences},
  volume={20 12},
Cooperativity, the ability of ligand binding at one site on a macromolecule to influence ligand binding at a different site on the same macromolecule, is a fascinating biological property that is often poorly explained in textbooks. The Hill coefficient is commonly used in biophysical studies of cooperative systems although it is not a quantitative measure of cooperativity. The free energy of interaction between binding sites (delta delta G) is a more stringent definition of cooperativity and… CONTINUE READING

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