Cooperatively folded proteins in random sequence libraries

@article{Davidson1995CooperativelyFP,
  title={Cooperatively folded proteins in random sequence libraries},
  author={Alan R. Davidson and K. Lumb and Robert T. Sauer},
  journal={Nature Structural Biology},
  year={1995},
  volume={2},
  pages={856-864}
}
The structural properties of proteins recovered from random sequence libraries can be used to investigate the relationship between folding and sequence information. Here, we show that helical proteins displaying cooperative thermal denaturation transitions can be easily recovered from a library containing 80-residue proteins predominantly composed of glutamine, leucine, and arginine, with an average hydophobicity level similar to that of natural proteins. The native structure of one of these… 

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