Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.

  title={Cooperative transcriptional activation by Klf4, Meis2, and Pbx1.},
  author={Glen A Bjerke and Cathy Hyman-Walsh and David Wotton},
  journal={Molecular and cellular biology},
  volume={31 18},
The Kruppel-like factor Klf4 is implicated in tumorigenesis and maintaining stem cell pluripotency, and Klf4 can both activate and repress gene expression. We show that the Pbx1 and Meis2 homeodomain proteins interact with Klf4 and can be recruited to DNA elements comprising a Klf4 site or GC box, with adjacent Meis and Pbx sites. Meis2d and Pbx1a activate expression of p15(Ink4a) and E-cadherin, dependent on the Meis2d transcriptional activation domain. In HepG2 cells, reducing expression of… CONTINUE READING
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