Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by exercise to facilitate nerve regeneration.

@article{Wilhelm2012CooperativeRO,
  title={Cooperative roles of BDNF expression in neurons and Schwann cells are modulated by exercise to facilitate nerve regeneration.},
  author={Jennifer C Wilhelm and Mei Q Xu and Delia Cucoranu and Sarah Chmielewski and Tiffany Holmes and Kelly Shukkwan Lau and Gary Jonathan Bassell and Arthur W English},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 14},
  pages={5002-9}
}
After peripheral nerve injury, neurotrophins play a key role in the regeneration of damaged axons that can be augmented by exercise, although the distinct roles played by neurons and Schwann cells are unclear. In this study, we evaluated the requirement for the neurotrophin, brain-derived neurotrophic factor (BDNF), in neurons and Schwann cells for the regeneration of peripheral axons after injury. Common fibular or tibial nerves in thy-1-YFP-H mice were cut bilaterally and repaired using a… CONTINUE READING