Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit.

@article{Brodt2001CooperativeRO,
  title={Cooperative regulation of the invasive and metastatic phenotypes by different domains of the type I insulin-like growth factor receptor beta subunit.},
  author={Pnina Brodt and Lucia Fallavollita and Abdel Majid Khatib and Amir Abbas Samani and Donglei Zhang},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 36},
  pages={33608-15}
}
The receptor for the type 1 insulin-like growth factor (IGF-I) regulates multiple cellular functions impacting on the metastatic phenotype of tumor cells, including cellular proliferation, anchorage-independent growth, survival, migration, synthesis of the 72-kDa type IV collagenase and invasion. We have used site-directed mutagenesis to generate domain-specific mutants of the receptor beta subunit to analyze the role of specific tyrosines in the regulation of the invasive/metastatic phenotype… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Regulation of the Metastatic Phenotype by the IGF-I Receptor 33615 by gest on O cber 27

  • M. Fornaro, C. A. Steger, A. M. Bennett, J. J. Wu, L. R. Languino
  • Mol. Biol. Cell 11,
  • 2000
1 Excerpt

Cell Adhesion and Invasion in Cancer Metastasis

  • P. Brodt
  • (Brodt, P.,
  • 1996
1 Excerpt

Similar Papers

Loading similar papers…