Cooperative regulation of myosin-actin interactions by a continuous flexible chain I: actin-tropomyosin systems.

@article{Smith2003CooperativeRO,
  title={Cooperative regulation of myosin-actin interactions by a continuous flexible chain I: actin-tropomyosin systems.},
  author={David A. Smith and Robin Maytum and Michael A. Geeves},
  journal={Biophysical journal},
  year={2003},
  volume={84 5},
  pages={3155-67}
}
We present a model for cooperative myosin binding to the regulated actin filament, where tropomyosins are treated as a weakly-confined continuous flexible chain covering myosin binding sites. Thermal fluctuations in chain orientation are initially required for myosin binding, leaving kinked regions under which subsequent myosins may bind without further distortion of the chain. Statistical mechanics predicts the fraction of sites with bound myosin-S1 as a function of their affinities. Published… CONTINUE READING