Cooperative regulation of myosin-S1 binding to actin filaments by a continuous flexible Tm–Tn chain

@inproceedings{Mijailovich2012CooperativeRO,
  title={Cooperative regulation of myosin-S1 binding to actin filaments by a continuous flexible Tm–Tn chain},
  author={Srboljub M. Mijailovich and O. Kayser-Herold and Xiaochuan Edward Li and H. W. Griffiths and Michael A. Geeves},
  booktitle={European Biophysics Journal},
  year={2012}
}
  • Srboljub M. Mijailovich, O. Kayser-Herold, +2 authors Michael A. Geeves
  • Published in European Biophysics Journal 2012
  • Chemistry, Medicine
  • The regulation of striated muscle contraction involves cooperative interactions between actin filaments, myosin-S1 (S1), tropomyosin (Tm), troponin (Tn), and calcium. These interactions are modeled by treating overlapping tropomyosins as a continuous flexible chain (CFC), weakly confined by electrostatic interactions with actin. The CFC is displaced locally in opposite directions on the actin surface by the binding of either S1 or Troponin I (TnI) to actin. The apparent rate constants for… CONTINUE READING

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