Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage.

@article{Kawaki2008CooperativeRO,
  title={Cooperative regulation of chondrocyte differentiation by CCN2 and CCN3 shown by a comprehensive analysis of the CCN family proteins in cartilage.},
  author={Harumi Kawaki and Satoshi Kubota and Akiko Suzuki and Noureddine Lazar and Tomohiro Yamada and Tatsushi Matsumura and Toshihiro Ohgawara and Takeyasu Maeda and Bernard Perbal and Karen M Lyons and Masaharu Takigawa},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2008},
  volume={23 11},
  pages={1751-64}
}
CCN2 is best known as a promoter of chondrocyte differentiation among the CCN family members, and its null mice display skeletal dysmorphisms. However, little is known concerning roles of the other CCN members in chondrocytes. Using both in vivo and in vitro approaches, we conducted a comparative analysis of CCN2-null and wildtype mice to study the roles of CCN2 and the other CCN proteins in cartilage development. Immunohistochemistry was used to evaluate the localization of CCN proteins and… CONTINUE READING
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CCN Proteins: A New Family of Cell Growth and Differentiation Regulators

  • B Perbal, M Takigawa
  • 2005

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