Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA

Abstract

During V(D)J recombination, recombination activating gene (RAG)1 and RAG2 bind and cleave recombination signal sequences (RSSs), aided by the ubiquitous DNA-binding/-bending proteins high-mobility group box protein (HMGB)1 or HMGB2. HMGB1/2 play a critical, although poorly understood, role in vitro in the assembly of functional RAG-RSS complexes, into which… (More)
DOI: 10.1093/nar/gks1461

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