Cooperative opioid and serotonergic mechanisms generate superior antidepressant-like effects in a mice model of depression.

Abstract

Although complete remission of symptoms is the goal of any depression treatment, many patients fail to attain or maintain a long-term, symptom-free status. The opioid system has been implicated in the aetiology of depression, and some preclinical and clinical data suggest that opioids possess a genuine antidepressant-like effect. This study aimed to… (More)
DOI: 10.1017/S1461145709000236

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