Cooperative mechanism of transcriptional activation by a cyclic AMP-response element modulator alpha mutant containing a motif for constitutive binding to CREB-binding protein.

@article{Fass2001CooperativeMO,
  title={Cooperative mechanism of transcriptional activation by a cyclic AMP-response element modulator alpha mutant containing a motif for constitutive binding to CREB-binding protein.},
  author={Daniel M. Fass and Johanna C Craig and Soren Impey and Richard Goodman},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 5},
  pages={2992-7}
}
Cyclic AMP-response element modulator alpha (CREMalpha) is a transcription factor that is highly related to cAMP-response element-binding protein (CREB) but represses cAMP-induced gene expression from simple artificial promoters containing a cAMP-response element (CRE). CREMalpha lacks two glutamine-rich Q regions that, in CREB, are thought to be necessary… CONTINUE READING