Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis.

@article{Giansanti1998CooperativeIB,
  title={Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis.},
  author={Maria Grazia Giansanti and Silvia Bonaccorsi and Briana D Williams and Erika V. Williams and C. Santolamazza and Michael L Goldberg and Maurizio Gatti},
  journal={Genes & development},
  year={1998},
  volume={12 3},
  pages={396-410}
}
We analyzed male meiosis in mutants of the chickadee (chic) locus, a Drosophila melanogaster gene that encodes profilin, a low molecular weight actin-binding protein that modulates F-actin polymerization. These mutants are severely defective in meiotic cytokinesis. During ana-telophase of both meiotic divisions, they exhibit a central spindle less dense than wild type; certain chic allelic combinations cause almost complete disappearance of the central spindle. Moreover, chic mutant… CONTINUE READING

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