Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity.


Androgen receptor (AR) transactivation is known to enhance prostate cancer cell survival. However, the precise effectors by which the prosurvival effects of androgen and AR drive prostate cancer progression are poorly defined. Here, we identify a novel feed-forward loop involving cooperative interactions between ligand-activated AR and heat-shock protein 27… (More)

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