Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif.

@article{Phelan1995CooperativeIB,
  title={Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif.},
  author={M. Phelan and I. Rambaldi and M. Featherstone},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15},
  pages={3989 - 3997}
}
Homeoprotein products of the Hox/HOM gene family pattern the animal embryo through the transcriptional regulation of target genes. We have previously shown that the labial group protein HOXA-1 has intrinsically weak DNA-binding activity due to residues in the N-terminal arm of its homeodomain (M. L. Phelan, R. Sadoul, and M. S. Featherstone, Mol. Cell. Biol. 14:5066-5075, 1994). This observation, among others, suggests that HOX and HOM proteins require cofactors for stable interactions with DNA… Expand
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