Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular development.

@article{Kubota2005CooperativeIO,
  title={Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular development.},
  author={Yoshiaki Kubota and Yuichi Oike and Shinya Satoh and Yoko Tabata and Yuichi Niikura and Tohru Morisada and Masaki Akao and Takashi Urano and Yasuhiro Ito and Takeshi Miyamoto and Norihiro Nagai and Gou Young Koh and Sumiko Watanabe and Toshio Suda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 38},
  pages={13502-7}
}
Angiopoietin-like protein (Angptl) 1 and Angptl2, which are considered orphan ligands, are highly homologous, particularly in the fibrinogen-like domain containing the putative receptor binding site. This similarity suggests potentially cooperative functions between the two proteins. In this report, the function of Angptl1 and Angptl2 is analyzed by using morpholino antisense technology in zebrafish. Knockdown of both Angptl1 and Angptl2 produced severe vascular defects due to increased… CONTINUE READING